I research biological "problem solving". When I say "problem solving", I'm referring to the set of actions that cells take towards achieving homeostasis. Examples include the selection of mutations that confer antibiotic resistance and the rewiring of metabolic flux after the deletion of a gene. I utilize reconstructed genome-scale networks of metabolism and expression as a base towards modeling such behavior. My current project involves elucidating the evolutionary trajectories of 7 different E. Coli strains using time-dependent genomic, fluxomic, and transcriptomic measurements.